??? ?????? 8 ?????? 2020 (??????) ???? ????? ??? ?????? ???????? (PDB) ????? ????????? ???????? ?????? ???????? ?????? ?????????( ??????? ????????? ???????) ?????? ?????? ??????? ?? ????? ???? ??? ??????? ?????? ?????? ???? ?? ??????.

????? ?????? ??? ??? ?????? ?? ????? ?????????? ?? ??? ????? (UCSD)? ??? ??? ?????? ?????? ?? ????? ??????? ??? ??? ??????? ?????? ??????? ?????? ????? ???? ?????? ???????? ?????? ??????? ??? ???? ??? ?????? ???????? ??????? ????????? ???????.

????? ?????? ????????? ???? ?? ????? ?? ??????? ?????? ???? ???????? ?????? ??? ?????? "????? ?????"? ???? ????? ?? ???? ?????? ?????? ????? ????? ?????? ????? ?????? ?????? ((3CL hydroase (Mpro))) ??? ????? ??? ?? ???? ????? ????? ?????? ???? ?? ????? ??????? ???????????.

???? ?? ?????? ?????? ??????? ?????? ??????? ????? ???? ??????? ??????.

????? ??? ???????? (PDB) ???? ???? ????? ????? ?????? ??? ???? ???? ??? ???????? ????? ?? ???? ????? ????? ?????? ???????? ?????? ????? ??????? ??????? ?? ???????? ????? ????? ???????.

?????? ????? ????? ?????? ?????? ((3CL hydroase (Mpro))? ??????? ???? ???? ????????? ???????? ?????? ???? ????? ??????? ????????? ???????. ??????? ??? ??? ???? ????? ?? ??????? ?????? ??? ?????? ????? ???? ?????? ?????????? ?????????? ????? ?????? ??????.

????? ????? ?. ?????? ?????? ??????? ????? ??? ???????? PDB? ???? ???? ??????? ?? ????? ?????? ?????? ?????????? "?? ????????? ??????? ?????? ?????? ???? ?????? ????? ???????? ???????? ????????".

????? "?? ????????? ??? ?????? ?????? ??????? ??????? ????? ?? ??? ??? PDB? ????? ??? ???? ???????? ????? ?????? ?????? ????? ??????? ?????? ??? ???? ???? ????? ???????? ???????? ?????????. ????? ??? ??? ??????? ???? ?????? ???????? ?????? ??? ???? ?????? ????????? ??????? ??????? ????????? ?? ????? ???? ???????? ?????? ?????????? ??? ????????".

???? ????? ?? ??? (PDB) ???? ?? ?? ????? ??? ?????? ???????? ???????? ???? ?????? ????? ???????? MERS? ???????? ???????? ??? ?????? ???? ??????? ?????? ?????? ?????? ??????.

???? ????? ????? (PDB) ???? ????? ?? ???? ????? ?????? ???? ?????? ???????? ((Worldwide Protein Data Bank)) ????? ????? ???????? ??????? ?? ???????? ??????? ??????? ?????. ?????? ??????? ??? ???? ?? 160 ???? ?? ??????? ?????? ??????? ????????? ?????? ?????? ???? ???? ????.